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Sunday sees the initial Wear-Tyne derby since 2024, but who will emerge victorious – Sunderland or Newcastle?
"Throughout the majority of last season, no one would have predicted Sunderland earning promotion and challenging with Eddie Howe's Newcastle, much less being above them in the table," remarked pundit Chris Sutton.
"It is very different now, and the way Sunderland play leads me to believe they've got a solid shot."
Sutton is making scoreline guesses for all 380 Premier League games this season, in competition with AI, the public and a range of guests.
For week 16, he faces off against England Gaming star Daniel 'Stingray' Ray.
Ray is vying for victory for the England's esports team – the Football Association's recognised esports team – at the EA Sports FC European esports championship finals tournament, which takes place at Twickenham Stadium on Saturday.
You can watch Uefa's YouTube, IG Live and TikTok channels, as well as EA Sports FC Twitch and its YouTube counterpart and England's Twitch.
Do you agree with their forecasts? Share your own predictions below.
The most commonly selected scoreline picked for each game is featured in the scoreboards at the end of this page.
Predicting the right outcome (choosing a win, draw or defeat) is worth 10 points. The exact score earns 40 points.
Ray, who represents his club side and the Premier League champions as well as England, is making his debut at the eEuros finals after passing the preliminary stage.
Eight players will represent their nations at the finals in a straight knockout, playing for a six-figure prize fund and a prestigious spot in the FC Pro World Championship Play-Ins, with the Danish representative Anders Vejrgang defending the title he won last year.
"My mindset is really good for it," Ray stated. "There's a really good coach alongside me and practice has been going well.
"It is invariably an honour to play for your country. Obviously when you are younger, you imagine doing it as an real-life footballer, but when you go into this field and there is an chance to represent England, putting the shirt on is something special.
"I overcame Vejrgang 9-4 in qualifying to get here. I've played against him over the course of the season just in practice, and in other tournaments before - but I'd never beaten him in a tournament before.
"I believe he is the number one in the world so defeating him in a tournament like this just provides a crazy boost of confidence."
Premier League Predictions
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The Blues were excellent against the Gunners at the end of November, when they earned a stalemate after being reduced to 10 men, and many thought here we go, they could potentially be challengers for the crown.
In the matches following, however, they were outfought by Leeds, looked lethargic against Bournemouth and this week got beaten by Atalanta in the Champions League.
So head coach Enzo Maresca is in need of a win here to get back on track, but it will be a challenge because the Merseyside club are such a potent team.
Kiernan Dewsbury-Hall and Iliman Ndiaye are playing really well and Everton have got a bit of form at the moment.
Based on recent performances you would likely back the visitors, while the most sensible prediction would probably be a draw, but I'm throwing caution to the wind.
The Blues have failed to given me any real reason to back them recently, but I just have a hunch they will win this match because they are at home and they are overdue a victory.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I'll be at this game and it will be intriguing to see what we get from the Reds.
I am really pleased for Reds boss Arne Slot to get such a important victory at Inter Milan on Tuesday after all the controversy with Mohamed Salah this week.
Slot should not have to put up with that nonsense. I know Salah has been a great for Liverpool but at its core Slot just wants to win games and there is no bias in his team selection.
They changed their formation against Inter and went with a midfield diamond and two up top.
All the talk is going to be talking about whether Salah is selected for this game, but the only way he is going to be reintegrated is if he makes amends.
Slot's attention will be on winning this game, but it is a tough one.
You could argue it is the same for most teams but I find Brighton so mercurial. I always feel they have got a goal in them, but they are defensively susceptible too.
Liverpool need to get back to winning consistently, but I am not sure how much their energy spent at the San Siro will have drained them.
I put a couple of Brighton players in my Fantasy Premier League side, so they will probably lose now - but I do fancy get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
Sunderland have had the week off while Newcastle had to battle intensely against Bayer Leverkusen on Wednesday, only to be pegged back late on.
Apart from their excellent performance against Everton a couple of weeks ago, Newcastle's away form hasn't been great, especially straight after they've played in the Champions League.
The pattern suggests that pattern to continue on Sunday, and their lack of freshness is likely to be a factor in how this game goes because of Sunderland's high press.
Their match against Arsenal demonstrated how incessant Regis le Bris's side are. They bullied the Gunners, and it was incredible to watch.
Everyone talks about how Granit Xhaka has been brilliant for the Black Cats, and he has been brilliant, but Noah Sadiki, who plays next to him, has also been one of the best acquisitions and deserves some attention too.
All signs point to this being the best game|most exciting fixture